DeFer-2

Chemical Structure : DeFer-2

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货号: PC-20653Not For Human Use, Lab Use Only.

DeFer-2 is an oleic acid (OA)-based ferritin-targeting PROTAC binding Kd of 17.1 uM, degrades ferritin and rapidly elevates the free iron content, induces pyroptosis.

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生物&药学活性

DeFer-2 is an oleic acid (OA)-based ferritin-targeting PROTAC binding Kd of 17.1 uM, degrades ferritin and rapidly elevates the free iron content, induces pyroptosis.
DeFer-2 caused the caspase 3-GSDME-mediated pyroptosis in cancer cells rather than typical ferroptosis, which is always associated with iron ion overload.
DeFer-2 (tailored albumin-based nano-formulation) substantially inhibited tumor growth and prolonged the survival time of mice bearing B16F10 subcutaneous tumors with negligible adverse effects.

物理化学性质&存储条件

分子量	780.13
分子式	C44H69N5O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C([C@H]1N(C([C@@H](NC(CCCNC(CCCCCCC/C=C\CCCCCCCC)=O)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2

参考文献

1. Yu Chen, et al. Journal of the American Chemical Society, April 24, 2023

DeFer-2

生物&药学活性

物理化学性质&存储条件

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DeFer-2

生物&药学活性

物理化学性质&存储条件

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