DSO-5a | BRS-3 agonist | Probechem Biochemicals

Chemical Structure : DSO-5a

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DSO-5a (Dimethyl Shikonin Oxime 5a)

货号: PC-20957Not For Human Use, Lab Use Only.

DSO-5a (Dimethyl shikonin oxime 5a) is a potent, selective agonist pf bombesin receptor subtype-3 (BB3, BRS-3) with pEC50 of 8.4 (IP-1 accumulation in hBB3-H1299 cells).

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生物&药学活性

DSO-5a (Dimethyl shikonin oxime 5a) is a potent, selective agonist pf bombesin receptor subtype-3 (BB3, BRS-3) with pEC50 of 8.4 (IP-1 accumulation in hBB3-H1299 cells).
DSO-5a did not elicit detectable calcium response in parental cells but elicited a strong calcium response in hBB3-H1299 cells with a pEC50 value of 7.964, Bantag-1 blocked these calcium responses in a dose-dependent manner.
DSO-5a induced a dose-dependent IP-1 accumulation with a pEC50 value of 7.262 in mBB3-HEK cells.
DSO-5a elicited IP-1 accumulation with pEC50 value of 9.357 in B16 cells.
DSO-5a (3 mg/kg; 10 mg/kg; 30 mg/kg) 30 min before glucose challenge (3 g/kg) reduced blood glucose excursions in a dose-dependent manner in C57BL/6 mice.

物理化学性质&存储条件

分子量	440.45
分子式	C23H24N2O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-((5Z,8E)-5,8-bis(hydroxyimino)-1,4-dimethoxy-5,8-dihydronaphthalen-2-yl)-2,2-dimethylbut-3-en-1-yl furan-2-carboxylate

参考文献

1. Lehao Wu, et al. J Med Chem. 2023 Jun 22;66(12):8011-8029.

DSO-5a (Dimethyl Shikonin Oxime 5a)

生物&药学活性

物理化学性质&存储条件

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DSO-5a (Dimethyl Shikonin Oxime 5a)

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物理化学性质&存储条件

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