DSM705 hydrochloride

Chemical Structure : DSM705 hydrochloride

CAS No.: 2989908-08-7

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货号: PC-23720Not For Human Use, Lab Use Only.

DSM705 hydrochloride (DSM 705) is a potent, highly selective, long-duration and orally bioavailable malaria DHODH inhibitor with IC50 of 95 nM (PfDHODH), and 52 nM (P. vivax DHODH).

规格	价格	库存
5 mg	￥2180	In stock
10 mg	￥3580	In stock
25 mg	￥5980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

DSM705 hydrochloride (DSM 705) is a potent, highly selective, long-duration and orally bioavailable malaria DHODH inhibitor with IC50 of 95 nM (PfDHODH), and 52 nM (P. vivax DHODH).
DSM705 shows no inhibition of mammalian DHODHs. DSM705 shows inhibitory activity against P. falciparum Pf3D7 cells (EC50=12 nM).
DSM705 (50 mg/kg, p.o.) fully suppresses parasitemia in vivo.

物理化学性质&存储条件

分子量	440.86
分子式	C19H20ClF3N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Methyl-N-[(1R)-1-(1H-1,2,4-triazol-5-yl)ethyl]-4-[1-[6-(trifluoromethyl)-3-pyridinyl]cyclopropyl]-1H-pyrrole-2-carboxamide hydrochloride

参考文献

1. Palmer MJ, et, al. J Med Chem. 2021 May 13;64(9):6085-6136.