DNDI-8219 |CAS:2222660-40-2 Probechem Biochemicals

Chemical Structure : DNDI-8219

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DNDI-8219 (DNDI8219)

货号: PC-63237Not For Human Use, Lab Use Only.

DNDI-8219 is a novel potent, orally active antileishmanial agent with IC50 of 0.19 uM against Leishmania donovani (L. don).

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生物&药学活性

DNDI-8219 is a novel potent, orally active antileishmanial agent with IC50 of 0.19 uM against Leishmania donovani (L. don); also has IC050 of 0.53 and 0.15 uM against L. inf and T. cruzi, displayes promising activity in the more stringent Leishmania infantum hamster model, with better solubility and pharmacokinetic properties, as well as minimal hERG inhibition.

物理化学性质&存储条件

分子量	345.234
分子式	C13H10F3N3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-nitro-6-(4-(trifluoromethoxy)phenoxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

参考文献

1. Thompson AM, et al. J Med Chem. 2018 Mar 22;61(6):2329-2352.

DNDI-8219 (DNDI8219)

生物&药学活性

物理化学性质&存储条件

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DNDI-8219 (DNDI8219)

生物&药学活性

物理化学性质&存储条件

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