DMXAA (ASA-404, Vadimezan)

Chemical Structure : DMXAA

CAS No.: 117570-53-3

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货号: PC-42754Not For Human Use, Lab Use Only.

DMXAA (ASA-404, Vadimezan) is a vascular disrupting agent (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 uM, also is a partial STING agonist, competes for human STING activation and STING dependent innate immune pathways.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1380	In stock
50 mg	￥2180	In stock
100 mg	￥3580	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

DMXAA (ASA-404, Vadimezan) is a vascular disrupting agent (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 uM, also is a partial STING agonist, competes for human STING activation and STING dependent innate immune pathways.

物理化学性质&存储条件

分子量	282.2906
分子式	C17H14O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 6.5 mg/mL
Chemical Name/SMILES	9H-Xanthene-4-acetic acid, 5,6-dimethyl-9-oxo-

参考文献

1. Phillips RM. Biochem Pharmacol. 1999 Jul 15;58(2):303-10.

2. Prantner D, et al. J Biol Chem. 2012 Nov 16;287(47):39776-88.

3. Shirey KA, et al. J Leukoc Biol. 2011 Mar;89(3):351-7.