DMU759 | TcKRS1 inhibitor | Probechem Biochemicals

Chemical Structure : DMU759

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DMU759 (DMU-759)

货号: PC-24979Not For Human Use, Lab Use Only.

DMU759 is a specific inhibitor of T. cruzi lysyl-tRNA synthetase 1 (TcKRS1) with IC50 of 15 nM, demonstrates potent activity against T. cruzi (Sylvio X10/7A1strain) with EC50 of 14 nM.

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生物&药学活性

DMU759 is a specific inhibitor of T. cruzi lysyl-tRNA synthetase 1 (TcKRS1) with IC50 of 15 nM, demonstrates potent activity against T. cruzi (Sylvio X10/7A1strain) with EC50 of 14 nM.
DMU759 is pan-active against all kinetoplastid parasites.
DMU759 binds to the ATP-binding pocket of KRS1.
DMU759 is not a potent inhibitor of the human ortholog of KRS1 with IC50 of >7000 nM.
DMU759 (50 mg/kg, twice a day) is capable of reducing parasitemia by up to 81% in mouse model of acute T. cruzi infection.

物理化学性质&存储条件

分子量	327.37
分子式	C15H16F3N3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-(cyclohexylthio)-5,6,8-trifluoro-2-methylquinazolin-4-amine

参考文献

1. Tulloch LB, et al. Sci Transl Med. 2025 Jul 9;17(806):eadu4564.

DMU759 (DMU-759)

生物&药学活性

物理化学性质&存储条件

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DMU759 (DMU-759)

生物&药学活性

物理化学性质&存储条件

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