DMU371

Chemical Structure : DMU371

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货号: PC-24978Not For Human Use, Lab Use Only.

DMU371 is a specific inhibitor of T. cruzi lysyl-tRNA synthetase 1 (TcKRS1) with IC50 of 185 nM, demonstrates potent activity against T. cruzi (Sylvio X10/7A1strain) with EC50 of 63 nM.

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生物&药学活性

DMU371 is a specific inhibitor of T. cruzi lysyl-tRNA synthetase 1 (TcKRS1) with IC50 of 185 nM, demonstrates potent activity against T. cruzi (Sylvio X10/7A1strain) with EC50 of 63 nM.
DMU371 is pan-active against all kinetoplastid parasites.
DMU371 binds to the ATP-binding pocket of KRS1.
DMU371 is not a potent inhibitor of the human ortholog of KRS1 with IC50 of >7000 nM.

物理化学性质&存储条件

分子量	296.30
分子式	C14H15F3N4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N7-cyclopentyl-5,6,8-trifluoro-2-methylquinazoline-4,7-diamine

参考文献

1. Tulloch LB, et al. Sci Transl Med. 2025 Jul 9;17(806):eadu4564.

DMU371

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DMU371

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