DDD508 | CpKRS inhibitor | Probechem Biochemicals

Chemical Structure : DDD508

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DDD508 (DDD-508)

货号: PC-23268Not For Human Use, Lab Use Only.

DDD508 is a potent, selective Cryptosporidium lysyl-tRNA synthetase (CpKRS) inhibitor with IC50 of 1.7 uM, and C. parvum EC50 of 0.13 uM, shows anti-cryptosporidials activity.

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生物&药学活性

DDD508 is a potent, selective Cryptosporidium lysyl-tRNA synthetase (CpKRS) inhibitor with IC50 of 1.7 uM, and C. parvum EC50 of 0.13 uM, shows anti-cryptosporidials activity.
DDD508 is selective over HsKRS (IC50=10 uM) and shows low cytotoxicity in HsHepG2 cells.
DDD508 is effective in key cryptosporidiosis mouse models.
DDD508 (15 mg/kg, BID) reduce parasite shedding and diarrheal scores in calves.
Overexpression or mutation of CpKRS (A309L mutation) confers resistance to DDD508.
DDD508 binds in a similar pose in the ATP site of CpKRS.

物理化学性质&存储条件

分子量	317.34
分子式	C17H19NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-hydroxy-N-((1-hydroxycyclohexyl)methyl)-4-oxo-4H-chromene-2-carboxamide

参考文献

1. Caldwell N, et al. Sci Transl Med. 2024 Oct 23;16(770):eadm8631.

DDD508 (DDD-508)

生物&药学活性

物理化学性质&存储条件

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DDD508 (DDD-508)

生物&药学活性

物理化学性质&存储条件

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