DDD489 | CpKRS inhibitor | Probechem Biochemicals

Chemical Structure : DDD489

加入收藏

DDD489 (DDD-489)

货号: PC-23267Not For Human Use, Lab Use Only.

DDD489 is a potent, selective Cryptosporidium lysyl-tRNA synthetase (CpKRS) inhibitor with IC50 of 0.85 uM, and C. parvum EC50 of 0.04 uM, shows anti-cryptosporidials activity.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

DDD489 is a potent, selective Cryptosporidium lysyl-tRNA synthetase (CpKRS) inhibitor with IC50 of 0.85 uM, and C. parvum EC50 of 0.04 uM, shows anti-cryptosporidials activity.
DDD489 is selective over HsKRS (IC50=22 uM) and shows low cytotoxicity in HsHepG2 cells.
DDD489 is effective in key cryptosporidiosis mouse models.
DDD489 (15 mg/kg, BID) reduce parasite shedding and diarrheal scores in calves.
Overexpression or mutation of CpKRS (A309L mutation) confers resistance to DDD489.
DDD489 binds in a similar pose in the ATP site of CpKRS.

物理化学性质&存储条件

分子量	382.31
分子式	C15H16F6N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-amino-4-(trifluoromethyl)-6-(((1R,3S)-3-(trifluoromethyl)cyclohexyl)methyl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-5-one

参考文献

1. Caldwell N, et al. Sci Transl Med. 2024 Oct 23;16(770):eadm8631.

DDD489 (DDD-489)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

DDD489 (DDD-489)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.