DBIBB |CAS:1569309-92-7 Probechem Biochemicals

Chemical Structure : DBIBB

CAS No.: 1569309-92-7

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DBIBB

货号: PC-60889Not For Human Use, Lab Use Only.

DBIBB is a potent and specific, nonlipid agonist of LPA2 receptor with EC50 of 100 nM, without activating or inhibiting LPA1/3/4/5 receptors.

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5 mg	￥2280	In stock
10 mg	￥3680	In stock
25 mg	￥5780	In stock
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生物&药学活性

DBIBB is a potent and specific, nonlipid agonist of LPA2 receptor with EC50 of 100 nM, without activating or inhibiting LPA1/3/4/5 receptors.
DBIBB displays 33-fold increased potency over GRI977143.
DBIBB mitigates the gastrointestinal radiation syndrome, increases intestinal crypt survival and enterocyte proliferation and reduces apoptosis.
DBIBB enhances DNA repair by augmenting the resolution of γ-H2AX foci, increases clonogenic survival of irradiated IEC-6 cells, attenuates the radiation-induced death of human CD34(+) hematopoietic progenitors and enhances the survival of the granulocyte/macrophage lineage in mice.

物理化学性质&存储条件

分子量	452.5
分子式	C23H20N2O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[[[4-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)butyl]amino]sulfonyl]-benzoic acid

参考文献

1. Patil R, et al. Chem Biol. 2015 Feb 19;22(2):206-16.

2. Knowlden SA, et al. Am J Respir Cell Mol Biol. 2016 Mar;54(3):402-9.

DBIBB

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DBIBB

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