Compound 4210 | MyD88 inhibitor | Probechem Biochemicals

Chemical Structure : Compound 4210

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Compound 4210 (MyD88 inhibitor 4210)

货号: PC-72669Not For Human Use, Lab Use Only.

Compound 4210 (MyD88 inhibitor 4210) is a small molecule inhibitor of MyD88, inhibits LPS-induced MyD88-mediated NF-kB-dependent expression of reporter activity with IC50 of 10-30 uM.

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生物&药学活性

Compound 4210 (MyD88 inhibitor 4210) is a small molecule inhibitor of MyD88, inhibits LPS-induced MyD88-mediated NF-kB-dependent expression of reporter activity with IC50 of 10-30 uM.
Compound 4210 4210 inhibited MyD88 dimer formation which is critical for pro-inflammatory signaling.
Compound 4210 inhibited inflammatory cytokine production in human primary cells and increased therapeutic efficacy in mice with exposure to toxins of both grampositive and gram-negative pathogens.
Compound 4210 exhibits broad spectrum antiviral activity by up regulation of type I interferon.

物理化学性质&存储条件

分子量	713.020
分子式	C44H64N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,4S)-N1-((R)-3-methyl-1-oxo-1-(pyrrolidin-1-yl)butan-2-yl)-N4-((S)-3-methyl-1-oxo-1-(pyrrolidin-1-yl)butan-2-yl)-N1,N4-bis(3-phenylpropyl)cyclohexane-1,4-dicarboxamide

参考文献

1. Shahabuddin Alam, et al. Chem Biol Drug Des. 2015 Aug;86(2):200-9.

2. Kamal U Saikh, et al. Antiviral Res. 2020 Sep;181:104854.

Compound 4210 (MyD88 inhibitor 4210)

生物&药学活性

物理化学性质&存储条件

参考文献

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Compound 4210 (MyD88 inhibitor 4210)

生物&药学活性

物理化学性质&存储条件

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