Collismycin A | Iron chelator | Probechem Biochemicals

Chemical Structure : Collismycin A

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Collismycin A (SF2738A, CMA)

货号: PC-24827Not For Human Use, Lab Use Only.

Collismycin A (CMA, SF2738A) is a microbial product produced by Streptomyces sp. with anti-proliferative activity against cancer cells, acts as a specific iron chelator and binds both Fe(II) and Fe(III) ions and forms a 2:1 chelator-iron complex with a redox-inactive center.

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生物&药学活性

Collismycin A (CMA, SF2738A) a microbial product produced by Streptomyces sp. with anti-proliferative activity against cancer cells, acts as a specific iron chelator and binds both Fe(II) and Fe(III) ions and forms a 2:1 chelator-iron complex with a redox-inactive center.
Collismycin A does not bind to other metal ions such as Zn(II), Mn(II), Cu(II), and Mg(II).
Collismycin A exhibits cell growth inhibition in various cancer cell lines (HeLa, IC50=0.3 uM).
Collismycin A induces cell cycle arrest at the G1 phase with a marked decrease of cyclin D1, affects the glycolytic pathway due to the accumulation of HIF-1α.
Collismycin A is active against a variety of bacteria (MICs=6.25 and 100 μg/mL) and fungi (MICs=12.5-100 μg/mL).

物理化学性质&存储条件

分子量	275.33
分子式	C13H13N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-4-Methoxy-5-(methylthio)-[2,2'-bipyridine]-6-carbaldehydeoxime

参考文献

1. Gomi, et al. J. Antibiot. (Tokyo) 47(12), 1385-1394 (1994).

2. Kawatani M, et al. Sci Rep. 2016 Dec 6:6:38385.

Collismycin A (SF2738A, CMA)

生物&药学活性

物理化学性质&存储条件

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Collismycin A (SF2738A, CMA)

生物&药学活性

物理化学性质&存储条件

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