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首页-小分子抑制剂&激动剂-GPCR-Histamine Receptor-Clobenpropit dihydrobromide
Clobenpropit dihydrobromide

Chemical Structure : Clobenpropit dihydrobromide

CAS No.: 145231-35-2

Clobenpropit dihydrobromide (VUF-9153;VUF9153)

货号: PC-35223Not For Human Use, Lab Use Only.

Clobenpropit (VUF-9153) is a highly potent histamine H3 antagonist/inverse agonist with pA2 value of 9.93, also displays partial agonist activity at H4 receptors.

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10 mg ¥1280 In stock
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50 mg ¥3280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Clobenpropit (VUF-9153) is a highly potent histamine H3 antagonist/inverse agonist with pA2 value of 9.93, also displays partial agonist activity at H4 receptors.
Clobenpropit (VUF-9153) increases brain histidine decarboxylase activity dose dependently, inhibits electrically induced convulsions in mice.

物理化学性质&存储条件

分子量 381.744
分子式 C14H19Cl3N4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-(1H-imidazol-4-yl)propyl (4-chlorobenzyl)carbamimidothioate dihydrochloride

参考文献

1. Yokoyama H, et al. Eur J Pharmacol. 1994 Jul 21;260(1):23-8.

2. Clark EA, et al. Br J Pharmacol. 1995 Jan;114(2):357-62.

3. Stark H, et al. J Med Chem. 1996 Mar 1;39(5):1157-63.

4. Mochizuki T, et al. Brain Res. 1996 Dec 16;743(1-2):178-83.

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