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首页-小分子抑制剂&激动剂-GPCR-Calcium-sensing Receptor (CaSR)-Cinacalcet hydrochloride
Cinacalcet hydrochloride

Chemical Structure : Cinacalcet hydrochloride

CAS No.: 364782-34-3

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Cinacalcet hydrochloride (AMG 073 hydrochloride;AMG073 hydrochloride;AMG-073 hydrochloride;Cinacalcet)

货号: PC-45942Not For Human Use, Lab Use Only.

Cinacalcet (AMG 073) hydrochloride is a calcimimetic agent that acts as an allosteric activator of CaSR.

规格 价格 库存 数量
50 mg ￥1280 In stock
100 mg ￥1980 In stock
200 mg ￥2980 In stock
1 g Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Cinacalcet (AMG 073) hydrochloride is a calcimimetic agent that acts as an allosteric activator of CaSR.
Cinacalcet (AMG 073) increases the concentration of cytoplasmic Ca(2+) in human embryonic kidney 293 cells expressing the human parathyroid CaR with EC50 of 51 nM.
Cinacalcet (AMG 073) decreases PTH secretion from cultured bovine parathyroid cells with IC50 of 28 nM.
Cinacalcet (AMG 073) is used for the treatment of tertiary hyperparathyroidism.

物理化学性质&存储条件

分子量 393.8729
分子式 C22H23ClF3N
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-Naphthalenemethanamine, .alpha.-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-, hydrochloride (1:1), (.alpha.R)-

参考文献

1. Nemeth EF, et al. J Pharmacol Exp Ther. 2004 Feb;308(2):627-35.

2. Lindberg JS, et al. Kidney Int. 2003 Jan;63(1):248-54.

3. Quarles LD, et al. J Am Soc Nephrol. 2003 Mar;14(3):575-83.

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