欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-GPCR-Calcium-sensing Receptor (CaSR)-Cinacalcet
Cinacalcet

Chemical Structure : Cinacalcet

CAS No.: 226256-56-0

加入收藏

Cinacalcet (AMG073, AMG-073)

货号: PC-45941Not For Human Use, Lab Use Only.

Cinacalcet (AMG073) is a calcimimetic agent that acts as an allosteric activator of CaSR with EC50 of 51 nM.

规格 价格 库存 数量
50 mg ￥880 In stock
100 mg ￥1280 In stock
250 mg ￥1980 In stock
1 g Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Cinacalcet (AMG073) is a calcimimetic agent that acts as an allosteric activator of CaSR with EC50 of 51 nM.
Cinacalcet (AMG073) increases the concentration of cytoplasmic Ca(2+) in human embryonic kidney 293 cells expressing the human parathyroid CaR with EC50 of 51 nM.
Cinacalcet (AMG073) decreases PTH secretion from cultured bovine parathyroid cells with IC50 of 28 nM.
Cinacalcet (AMG073) is used for the treatment of tertiary hyperparathyroidism.

物理化学性质&存储条件

分子量 357.412
分子式 C22H22F3N
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-Naphthalenemethanamine, .alpha.-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-, (.alpha.R)-

参考文献

1. Nemeth EF, et al. J Pharmacol Exp Ther. 2004 Feb;308(2):627-35.

2. Lindberg JS, et al. Kidney Int. 2003 Jan;63(1):248-54.

3. Quarles LD, et al. J Am Soc Nephrol. 2003 Mar;14(3):575-83.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: