Chk1 PROTAC-2

Chemical Structure : Chk1 PROTAC-2

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货号: PC-21717Not For Human Use, Lab Use Only.

Chk1 PROTAC-2 is a potent Chk1 degrader with DC50 of 1.33 µM in A375 cells.

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生物&药学活性

Chk1 PROTAC-2 is a potent Chk1 degrader with DC50 of 1.33 µM in A375 cells.
Chk1 degradation by PROTAC-2 is inhibited in the presence of MG132 and pomalidomide, suggesting that CHK1 degradation occurs via the proteasome and cereblon.

物理化学性质&存储条件

分子量	900.91
分子式	C43H44N14O9
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((4-(cyanomethyl)phenyl)amino)-6-((5-cyclopropyl-1H-pyrazol-3-yl)amino)-N-((1-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)ethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)methyl)pyrimidine-4-carboxamide

参考文献

1. Sandipan Roy Chowdhury, et al. bioRxiv. 2024 Jan 1:2023.12.30.573733.

Chk1 PROTAC-2

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物理化学性质&存储条件

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Chk1 PROTAC-2

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物理化学性质&存储条件

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