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首页-小分子抑制剂&激动剂-GPCR-mAChR-Cevimeline
Cevimeline

Chemical Structure : Cevimeline

CAS No.: 107233-08-9

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Cevimeline (AF-102B;FKS-508)

货号: PC-45938Not For Human Use, Lab Use Only.

A potent M1-selective muscarinic agonist.

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10 mg ￥880 In stock
50 mg ￥3600 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

A potent M1-selective muscarinic agonist; decreases the K+-evoked [3H]ACh release from hippocampal synaptosomes and increases the K+-evoked [3H]DA release from striatal synaptosomes; attenuates cognitive dysfunctions in AF64A-treated rats with low toxicity.

Other Indication

Approved

物理化学性质&存储条件

分子量 199.3131
分子式 C10H17NOS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Spiro[1-azabicyclo[2.2.2]octane-3,5'-[1,3]oxathiolane], 2'-methyl-, (2'R,3R)-rel-

参考文献

1. Ono S, et al. Eur J Pharmacol. 1988 Oct 11;155(1-2):77-84.

2. Fisher A, et al. Neurosci Lett. 1989 Jul 31;102(2-3):325-31.

3. Nakahara N, et al. Jpn J Pharmacol. 1989 Dec;51(4):539-47.

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