Calindol hydrochloride |CAS:729610-18-8 Probechem Biochemicals

Chemical Structure : Calindol hydrochloride

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Calindol hydrochloride

货号: PC-62910Not For Human Use, Lab Use Only.

Calindol hydrochloride is a calcimimetic acting agent and positive allosteric modulator (agonist) of CaSR with EC50 of 0.31 uM (stimulated 3H IP accumulation in CHO cells at 2 mM Ca2+).

规格	价格	库存	数量
100 mg		Get quote
250 mg		Get quote
500 mg		Get quote
1 g		Get quote

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生物&药学活性

Calindol hydrochloride is a calcimimetic acting agent and positive allosteric modulator (agonist) of CaSR with EC50 of 0.31 uM (stimulated 3H IP accumulation in CHO cells at 2 mM Ca2+); activates an extracellular ligand-binding domain-deleted rhodopsin-like seven-transmembrane structure in the absence of Ca(2+); produces concentration-dependent hyperpolarizations of vascular myocytes from rat isolated mesenteric and porcine coronary arteries.

物理化学性质&存储条件

分子量	336.863
分子式	C21H21ClN2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[(1R)-1-(1-naphthalenyl)ethyl]-1H-indole-2-methanamine, monohydrochloride

参考文献

1. Kessler A, et al. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3345-9.

2. Weston AH, et al. Circ Res. 2005 Aug 19;97(4):391-8.

3. Ray K, et al. J Biol Chem. 2005 Nov 4;280(44):37013-20.