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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Fungal-CZx-243
CZx-243

Chemical Structure : CZx-243

CAS No.:

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CZx-243 (CZx243)

货号: PC-27313Not For Human Use, Lab Use Only.

CZx-243 is a highly stable and orally bioavailable CYP51 inhibitor, exhibits potent, broad-spectrum in vitro activity against Candida and Cryptococcus species, including fluconazole-resistant strains (MIC=0.00625-0.25 μg/mL).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

CZx-243 is a highly stable and orally bioavailable CYP51 inhibitor, exhibits potent, broad-spectrum in vitro activity against Candida and Cryptococcus species, including fluconazole-resistant strains (MIC=0.00625-0.25 μg/mL).

物理化学性质&存储条件

分子量 506.94
分子式 C27H21ClF2N4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-(4-chlorophenyl)-2-((2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl)isoquinolin-1(2H)-one

参考文献

1. Luo Z, et al. J Med Chem. 2026 Jul 14. doi: 10.1021/acs.jmedchem.6c01073.

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