Silmitasertib (CX4945) |CAS:1009820-21-6 Probechem Biochemicals

Chemical Structure : CX4945

CAS No.: 1009820-21-6

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CX4945 (Silmitasertib, CX-4945)

货号: PC-45870Not For Human Use, Lab Use Only.

CX-4945 (Silmitasertib, CX4945) is a potent, selective, orally bioavailable, ATP-competitive inhibitor of protein kinase Casein Kinase 2 (CK2) with Ki of 0.38 nM, CK2α IC50 of 1 nM.

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2 mg (Free Sample)	￥180	In stock
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

CX4945 (Silmitasertib, CX-4945) is a potent, selective, orally bioavailable, ATP-competitive inhibitor of protein kinase Casein Kinase 2 (CK2) with Ki of 0.38 nM, CK2α IC50 of 1 nM.
CX4945 (Silmitasertib) displays good selectivity profile against a panel of 238 kinases.
CX4945 (Silmitasertib) attenuates PI3K/Akt signaling, blocks CK2-dependent HIF-1α transcription, caused cell cycle arrest and selectively induces apoptosis in cancer cells relative to normal cells.
CX4945 (Silmitasertib) exhibits antitumor efficacy in murine xenograft models.

物理化学性质&存储条件

分子量	349.7705
分子式	C19H12ClN3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 35 mg/mL
Chemical Name/SMILES	Benzo[c]-2,6-naphthyridine-8-carboxylic acid, 5-[(3-chlorophenyl)amino]-

参考文献

1. Pierre F, et al. J Med Chem. 2011 Jan 27;54(2):635-54.

2. Siddiqui-Jain A, et al. Cancer Res. 2010 Dec 15;70(24):10288-98.

3. Siddiqui-Jain A, et al. Mol Cancer Ther. 2012 Apr;11(4):994-1005.

CX4945 (Silmitasertib, CX-4945)

生物&药学活性

物理化学性质&存储条件

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CX4945 (Silmitasertib, CX-4945)

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物理化学性质&存储条件

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