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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Casein Kinase-CX-5011
CX-5011

Chemical Structure : CX-5011

CAS No.: 1333382-30-1

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CX-5011 (CX5011)

货号: PC-22790Not For Human Use, Lab Use Only.

CX-5011 is a potent, selective inhibitor of protein kinase CK2 with IC50 of <10 nM, induces cell death by apoptosis and acts synergistically with imatinib or the MEK-inhibitor U0126 in imatinib-resistant CML cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

CX-5011 is a potent, selective inhibitor of protein kinase CK2 with IC50 of <10 nM, induces cell death by apoptosis and acts synergistically with imatinib or the MEK-inhibitor U0126 in imatinib-resistant CML cells.

物理化学性质&存储条件

分子量 362.32
分子式 C20H11N4NaO2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

sodium 5-(3-ethynylphenylamino)pyrimido[4,5-c]quinoline-8-carboxylate

参考文献

1. Anderes K, et al. Biochemistry. 2011 Oct 4;50(39):8478-88.

2. Salizzato V, et al. Oncotarget. 2016 Apr 5;7(14):18204-18.

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