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CWHM-117

Chemical Structure : CWHM-117

CAS No.: 1505452-80-1

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CWHM-117 (CWHM117)

货号: PC-49831Not For Human Use, Lab Use Only.

CWHM-117 is potent nanomolar inhibitor of the Plasmodium aspartic proteases PM-II and PM-IV with IC50 of 4 and 15 nM respectively, exhibits IC50 of 463 nM in the Pf 3D7 infected RBC assays.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    CWHM-117 is potent nanomolar inhibitor of the Plasmodium aspartic proteases PM-II and PM-IV with IC50 of 4 and 15 nM respectively, exhibits IC50 of 463 nM in the Pf 3D7 infected RBC assays.
    CWHM-117 is >1000-fold selective for PM-II over BACE and CatD and 300-fold over CatE.
    CWHM-117 exhibits potent antimalarial potency while reducing inhibition of human aspartic proteases such as BACE.

    物理化学性质&存储条件

    分子量 393.49
    分子式 C23H27N3O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-cyclohexyl-2-imino-5,5-bis(4-methoxyphenyl)imidazolidin-4-one

    参考文献

    1. Marvin J Meyers, et al. ACS Med Chem Lett. 2013 Dec 6;5(1):89-93.

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