CTCB-405 | TbPFK inhibitor | Probechem Biochemicals

Chemical Structure : CTCB-405

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CTCB-405 (CTCB405)

货号: PC-72583Not For Human Use, Lab Use Only.

CTCB-405 (CTCB405) is a small molecule allosteric inhibitor of T. brucei phosphofructokinase (TbPFK) with IC50 of 0.18 uM, ITC Kd of 92 nM, no significant inhibition of human PFKs.

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生物&药学活性

CTCB-405 (CTCB405) is a small molecule allosteric inhibitor of T. brucei phosphofructokinase (TbPFK) with IC50 of 0.18 uM, ITC Kd of 92 nM, no significant inhibition of human PFKs.
CTCB-405 demonstrated in vitro parasite killing potency of the bloodstream form of T. brucei strain Lister 427 (EC50=0.37 uM).
CTCB-405 (50, 100 mg/kg) clear parasites in a stage 1 model of HAT infection with 1-day oral dosing and show reduction of parasitaemia in the brain in a pleiomorphic model.

物理化学性质&存储条件

分子量	364.27
分子式	C18H19Cl2N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3,4-dichlorobenzyl)-5-(2-(dimethylamino)ethyl)-1,5-dihydro-4H-pyrrolo[3,2-c]pyridin-4-one

参考文献

1. Iain W McNae, et al. Nat Commun. 2021 Feb 16;12(1):1052.

CTCB-405 (CTCB405)

生物&药学活性

物理化学性质&存储条件

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CTCB-405 (CTCB405)

生物&药学活性

物理化学性质&存储条件

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