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首页-小分子抑制剂&激动剂-Others-Small GTPase-CPYPP
CPYPP

Chemical Structure : CPYPP

CAS No.: 310460-39-0

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CPYPP

货号: PC-62450Not For Human Use, Lab Use Only.

CPYPP is a small-molecule inhibitor of the Rac activator DOCK2 with IC50 of 22.8 uM (DOCK2DHR-2-mediated Rac GEF activity), inhibits DOCK2-Rac1 interaction.

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10 mg ￥1480 In stock
25 mg ￥2580 In stock
50 mg ￥3980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CPYPP is a small-molecule inhibitor of the Rac activator DOCK2 with IC50 of 22.8 uM (DOCK2DHR-2-mediated Rac GEF activity), inhibits DOCK2-Rac1 interaction.
CPYPP binds to DOCK2 DHR-2 domain in a reversible manner and inhibited its catalytic activity in vitro.
CPYPP blocks both chemokine receptor- and antigen receptor-mediated Rac activation in lymphocytes, resulting in marked reduction of chemotactic response and T cell activation.

物理化学性质&存储条件

分子量 324.764
分子式 C18H13ClN2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-[3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione

参考文献

1. Nishikimi A, et al. Chem Biol. 2012 Apr 20;19(4):488-97.

2. Watanabe M, et al. J Immunol. 2014 Dec 1;193(11):5660-7.

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