CM 764 |CAS:1350296-29-5 Probechem Biochemicals

Chemical Structure : CM764

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CM764 (C764;CM-764)

货号: PC-60750Not For Human Use, Lab Use Only.

CM764 is a potent, selective sigma-2 receptor agonist with Ki of 3.5 nM, 25-fold selectivity over sigma-1 receptors (Ki=86.6 nM).

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生物&药学活性

CM764 is a potent, selective sigma-2 receptor agonist with Ki of 3.5 nM, 25-fold selectivity over sigma-1 receptors (Ki=86.6 nM).
CM764 increases reduction of MTT in human SK-N-SH neuroblastoma, produces an immediate, robust, and transient increase in cytosolic calcium, consistent with sigma-2 receptor activation.
CM764 increases total NAD(+)/NADH level, the ATP level, HIF1α and VEGF levelsin SK-N-SH cells.

物理化学性质&存储条件

分子量	426.492
分子式	C23H27FN4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-acetyl-3-(4-(4-(2-amino-4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one

参考文献

1. Nicholson H, et al. J Pharmacol Exp Ther. 2016 Feb;356(2):232-43.

CM764 (C764;CM-764)

生物&药学活性

物理化学性质&存储条件

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CM764 (C764;CM-764)

生物&药学活性

物理化学性质&存储条件

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