CKR-49-17

Chemical Structure : CKR-49-17

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货号: PC-21547Not For Human Use, Lab Use Only.

CKR-49-17 is a potent, allosteric small molecule activator of CK1γ2 with Kd value of 180 nM in MST assays.

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生物&药学活性

CKR-49-17 is a potent, allosteric small molecule activator of CK1γ2 with Kd value of 180 nM in MST assays.
CKR-49-17 increases phosphorylation of Presenilin 1 (PS1)-pS367 in vitro with IC50 of 60 uM.
CKR-49-17 shows binding affinity for CK1γ2 D128A mutant with SPR Kd of 750 nM.
CKR-49-17 decreased C99 levels with IC50 of 15 uM in N2A cells stably overexpressing APP-695, decreased the levels of Aβ40 and Aβ42.

物理化学性质&存储条件

分子量	391.49
分子式	C21H21N5OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(6-cyanobenzo[d]thiazol-2-yl)-4-((piperidin-4-ylamino)methyl)benzamide

参考文献

1. Bustos VH, et al. ACS Chem Biol. 2023 Dec 11. doi: 10.1021/acschembio.3c00425.

CKR-49-17

生物&药学活性

物理化学性质&存储条件

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CKR-49-17

生物&药学活性

物理化学性质&存储条件

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