CK2 inhibitor D11 |CAS:1803427-24-8 Probechem Biochemicals

Chemical Structure : CK2 inhibitor D11

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CK2 inhibitor D11 (D11)

货号: PC-60577Not For Human Use, Lab Use Only.

CK2 inhibitor D11 is a potent, selective, cell permeab anti-apoptotic protein kinase CK2 with Ki of 5 nM.

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生物&药学活性

CK2 inhibitor D11 is a potent, selective, cell permeab anti-apoptotic protein kinase CK2 with Ki of 5 nM.
D11 potently inhibits CK2α with IC50 of 7 nM, shows <2% remaining kinase activity against a panel of 354 eukaryotic protein kinases with exception of DYRK1B, PIM3 and IRAK1 (IC50=20-50 nM).
D11 inhibits the phosphorylation of the CK2 biomarker CDC37 at S13 in MIA PaCa-2 cells, also inhibits S380/T382/383 phosphorylation in PTEN in NSCLC cells.

物理化学性质&存储条件

分子量	402.227
分子式	C20H13Cl2NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,3-Dichloro-6-[(E)-((4-methoxyphenyl)imino)methyl] dibenzo(b,d) furan-2,7-diol

参考文献

1. Guerra B, et al. Mol Cell Biochem. 2015 Aug;406(1-2):151-61.

CK2 inhibitor D11 (D11)

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物理化学性质&存储条件

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CK2 inhibitor D11 (D11)

生物&药学活性

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