CDK9 degrader PO-8

Chemical Structure : CDK9 degrader PO-8

加入收藏

货号: PC-25541Not For Human Use, Lab Use Only.

CDK9 degrader PO-8 is a potent, selective iCDK9-based PROTAC degrader of CDK9 with DC50 of 0.26 uM in RAW 264.7 cells.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

CDK9 degrader PO-8 is a potent, selective iCDK9-based PROTAC degrader of CDK9 with DC50 of 0.26 uM in RAW 264.7 cells.
PO-8 does not affect CDKs (CDK1, CDK2, CDK4, CDK6, and CDK7).
PO-8′s degradation mechanism relies on CRBN-mediated ubiquitination.
PO-8 exhibits dose-dependent inhibition of LPS-induced inflammation in RAW264.7 cells.
PO-8 suppresses the JAK2-STAT3 signaling pathway by degrading CDK9
PO-8 (5-10 mg/kg) attenuates LPS-induced acute lung injury in LPS-induced murine acute lung injury (ALI) model, robustly suppresses LPS induced a pronounced upregulation of pro-inflammatory cytokines such as IL-6, IL-1β, and TNF-α.

物理化学性质&存储条件

分子量	823.37
分子式	C44H48ClFN8O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((1r,4r)-4-((5'-chloro-6-((3-fluorobenzyl)amino)-[2,4'-bipyridin]-2'-yl)amino)cyclohexyl)-8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)octanamide

参考文献

1. Ao MT, et al. Biochem Pharmacol. 2025 Sep 19:117341.