CDK9 degrader AZ-9

Chemical Structure : CDK9 degrader AZ-9

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货号: PC-24813Not For Human Use, Lab Use Only.

CDK9 degrader AZ-9 is a potent, ATG101-recruiting selective CDK9 degrader, significantly degrades CDK9 and Cyclin T1 with DC50 of 0.4073 and 1.215 uM in HCT116 cells.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

CDK9 degrader AZ-9 is a potent, ATG101-recruiting selective CDK9 degrader, significantly degrades CDK9 and Cyclin T1 with DC50 of 0.4073 and 1.215 uM in HCT116 cells.
CDK9 degrader AZ-9 shows no significant on other cell cycle CDKs (CDK2, CDK4, and CDK6).
CDK9 degrader AZ-9 promotes classic downstream pathway related to CDK9, induces autophagy–lysosome pathway degradation of CDK9 by recruiting ATG101.
CDK9 degrader AZ-9 (50 mg/kg, po or 20 mg/kg i.p.) shows significant CDK9 degradation and downstream pathway effects in HCT116 xenograft model.

物理化学性质&存储条件

分子量	637.56
分子式	C32H34Cl2N6O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2,6-dichlorobenzamido)-N-(1-(4-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino)-4-oxobutanoyl)piperidin-4-yl)-1H-pyrazole-3-carboxamide

参考文献

1. Ye Zhong, et al. Acta Pharm Sin B. 2025 May;15(5):2612-2624.