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首页-抗体药物偶连体和PROTACs-PROTAC-CCT400028
CCT400028

Chemical Structure : CCT400028

CAS No.:

CCT400028 (CCT-400028)

货号: PC-26015Not For Human Use, Lab Use Only.

CCT400028 is a second-generation alisertib-derived Aurora A PROTAC with DC50 of 29 nM in MV4-11 leukemia cells, D max=85%, shows excellent selectivity in proteomic and kinase selectivity profiling.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

CCT400028 is a second-generation alisertib-derived Aurora A PROTAC with DC50 of 29 nM in MV4-11 leukemia cells, D max=85%, shows excellent selectivity in proteomic and kinase selectivity profiling.

物理化学性质&存储条件

分子量 878.40
分子式 C47H49ClFN7O7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-((9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[c]pyrimido[4,5-e]azepin-2-yl)amino)-N-(5-((5-(4-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)phenoxy)pentyl)oxy)pentyl)-2-methoxybenzamide

参考文献

1. O'Hanlon JA, et al. J Med Chem. 2026 Jan 22;69(2):1552-1567.

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