CB-64D |CAS:157752-20-0 Probechem Biochemicals

Chemical Structure : CB-64D

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CB-64D (CB 64D;CB64D)

货号: PC-60748Not For Human Use, Lab Use Only.

CB-64D is a potent, selective sigma-2 receptor agonist with Ki of 16.5 nM, 200-fold selectivity over sigma 1 (Ki=3063 nM).

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1 g		Get quote

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生物&药学活性

CB-64D is a potent, selective sigma-2 receptor agonist with Ki of 16.5 nM, 200-fold selectivity over sigma 1 (Ki=3063 nM).
CB-64D significantly induces the calcium signal and cell death in SK-N-SH cells, produces dose-dependent cytotoxicity.
CB-64D induces apoptosis in MCF-7 and T47D breast tumor cell lines.

物理化学性质&存储条件

分子量	333.431
分子式	C22H23NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1S,5R,8E)-8-benzylidene-5-(3-hydroxyphenyl)-2-methyl-2-azabicyclo[3.3.1]nonan-7-one

参考文献

1. Nicholson H, et al. J Pharmacol Exp Ther. 2015 Aug;354(2):203-12.

2. Bowen WD, et al. Eur J Pharmacol. 1995 May 24;278(3):257-60.

3. Vilner BJ, et al. J Pharmacol Exp Ther. 2000 Mar;292(3):900-11.

4. Crawford KW, et al. Cancer Res. 2002 Jan 1;62(1):313-22.

CB-64D (CB 64D;CB64D)

生物&药学活性

物理化学性质&存储条件

参考文献

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CB-64D (CB 64D;CB64D)

生物&药学活性

物理化学性质&存储条件

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