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首页-小分子抑制剂&激动剂-Others-Small GTPase-CASIN
CASIN

Chemical Structure : CASIN

CAS No.: 425399-05-9

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CASIN

货号: PC-43277Not For Human Use, Lab Use Only.

CASIN is a specific inhibitor of small RhoGTPase Cdc42, inhibits PIP2-stimulated actin polymerization in Xenopus egg extracts with IC50 of 2 uM.

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5 mg ￥780 In stock
10 mg ￥1280 In stock
25 mg ￥1980 In stock
50 mg ￥3280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CASIN is a specific inhibitor of small RhoGTPase Cdc42, inhibits PIP2-stimulated actin polymerization in Xenopus egg extracts with IC50 of 2 uM.
CASIN functionally rejuvenates aged HSCs, increases the percentage of polarized cells in an aged HSC population, and restores the level and spatial distribution of histone H4 lysine 16 acetylation to a status similar to that seen in young HSCs.
CASIN affects midbody trafficking of Rab8a vesicle and cytokinesis in cells.

物理化学性质&存储条件

分子量 306.4015
分子式 C20H22N2O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 31 mg/mL
Chemical Name/SMILES

Ethanol, 2-[(2,3,4,9-tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]-

参考文献

1. Florian MC, et al. Cell Stem Cell. 2012 May 4;10(5):520-30.

2. Sakamori R, et al. J Clin Invest. 2012 Mar;122(3):1052-65.

3. Peterson JR, et al. Chem Biol. 2006 Apr;13(4):443-52.

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