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Bragsin2

Chemical Structure : Bragsin2

CAS No.: 342795-08-8

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Bragsin2 (Bragsin 2)

货号: PC-36078Not For Human Use, Lab Use Only.

Bragsin2 (Bragsin 2) is a specific inhibitor of the ArfGEF BRAG2, affects the trans-Golgi network in a BRAG2- and Arf-dependent manner in cells (IC50=3 uM).

规格 价格 库存 数量
5 mg ￥880 In stock
10 mg ￥1280 In stock
25 mg ￥1880 In stock
50 mg ￥2980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Bragsin2 (Bragsin 2) is a specific inhibitor of the ArfGEF BRAG2, affects the trans-Golgi network in a BRAG2- and Arf-dependent manner in cells (IC50=3 uM).
Bragsin2 binds at the interface between the PH domain of BRAG2 and the lipid bilayer to render BRAG2 unable to activate lipidated Arf, requires membranes for specific inhibition of BRAG2; affects tumorsphere formation in breast cancer cell lines.
Bragsin1 and Bragsin 2 are novel compounds that function by altering protein-membrane interactions without disruption.

物理化学性质&存储条件

分子量 289.166
分子式 C11H6F3NO5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-methoxy-5-nitro-2-(trifluoromethyl)-4H-chromen-4-one

参考文献

1. Nawrotek A, et al. Nat Chem Biol. 2019 Feb 11. doi: 10.1038/s41589-019-0228-3.

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