Bragsin1 |CAS:369631-68-5 Probechem Biochemicals

Chemical Structure : Bragsin1

CAS No.: 369631-68-5

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Bragsin1 (Bragsin 1)

货号: PC-36077Not For Human Use, Lab Use Only.

Bragsin1 (Bragsin 1) is a specific inhibitor of the ArfGEF BRAG2, affects the trans-Golgi network in a BRAG2- and Arf-dependent manner in cells (IC50=3 uM).

规格	价格	库存
5 mg	￥1580	In stock
10 mg	￥2380	In stock
25 mg	￥3980	In stock
50 mg	￥5980	In stock
100 mg		Get quote

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生物&药学活性

Bragsin1 (Bragsin 1) is a specific inhibitor of the ArfGEF BRAG2, affects the trans-Golgi network in a BRAG2- and Arf-dependent manner in cells (IC50=3 uM).
Bragsin1 binds at the interface between the PH domain of BRAG2 and the lipid bilayer to render BRAG2 unable to activate lipidated Arf, requires membranes for specific inhibition of BRAG2.
Bragsin1 affects tumorsphere formation in breast cancer cell lines.
Bragsin1 and Bragsin 2 are novel compounds that function by altering protein-membrane interactions without disruption.

物理化学性质&存储条件

分子量	273.167
分子式	C11H6F3NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-methyl-5-nitro-2-(trifluoromethyl)-4H-chromen-4-one

参考文献

1. Nawrotek A, et al. Nat Chem Biol. 2019 Feb 11. doi: 10.1038/s41589-019-0228-3.

Bragsin1 (Bragsin 1)

生物&药学活性

物理化学性质&存储条件

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Bragsin1 (Bragsin 1)

生物&药学活性

物理化学性质&存储条件

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