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Bm-MPK1-IN-15b

Chemical Structure : Bm-MPK1-IN-15b

CAS No.: 2222294-62-2

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Bm-MPK1-IN-15b

货号: PC-63332Not For Human Use, Lab Use Only.

Bm-MPK1-IN-15b is a potent, orally bioavailable inhibitor of B. malayi stress-activated kinase Bm-MPK1 with IC50 of 24 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Bm-MPK1-IN-15b is a potent, orally bioavailable inhibitor of B. malayi stress-activated kinase Bm-MPK1 with IC50 of 24 nM; inhibits human p38α and JNK3 with IC50 of 26 and 170 nM, respectively; reduces the motility of adult worms at 100 nM, Bm-MPK1-IN-15b is a tool compound for in vivo studies aimed at strengthening the role of Bm MPK1 in B. malayi response to host oxidative stress.

    物理化学性质&存储条件

    分子量 391.475
    分子式 C22H25N5O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-((1r,4r)-4-((4-(5-methyl-3-phenylisoxazol-4-yl)pyrimidin-2-yl)amino)cyclohexyl)acetamide

    参考文献

    1. Tummalapalli SR, et al. ACS Med Chem Lett. 2018 Feb 9;9(3):210-214.

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