Bischof-5 |CAS:1446200-49-2 Probechem Biochemicals

Chemical Structure : Bischof-5

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Bischof-5 (Bischof 5;Bischof5;CK1δ inhibitor 5)

货号: PC-60581Not For Human Use, Lab Use Only.

Bischof-5 (CK1δ inhibitor 5) is a potent, specific casein kinase 1δ (CK1δ) inhibitor with IC50 of 40 nM.

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生物&药学活性

Bischof-5 (CK1δ inhibitor 5) is a potent, specific casein kinase 1δ (CK1δ) inhibitor with IC50 of 40 nM.
Bischof-5 exhibits 5-fold higher affinity towards CK1δ than to CK1ε (IC50=199 nM), demonstrates good selectivity against a panel of over 442 kinases.
Bischof-5 inhibits proliferation of tumor cell lines in a dose and cell line specific manner.

物理化学性质&存储条件

分子量	515.39
分子式	C20H11F6N5O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-(trifluoromethoxy)benzamido)-N-(6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)thiazole-4-carboxamide

参考文献

1. Bischof J, et al. Amino Acids. 2012 Oct;43(4):1577-91.

2. Bibian M, et al. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4374-80.

Bischof-5 (Bischof 5;Bischof5;CK1δ inhibitor 5)

生物&药学活性

物理化学性质&存储条件

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Bischof-5 (Bischof 5;Bischof5;CK1δ inhibitor 5)

生物&药学活性

物理化学性质&存储条件

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