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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Trk Receptor-Belizatinib
Belizatinib

Chemical Structure : Belizatinib

CAS No.: 1357920-84-3

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Belizatinib (TSR-011, TSR011)

货号: PC-70256Not For Human Use, Lab Use Only.

Belizatinib (TSR-011) is a potent, dual ALK and TrkA, TrkB and TrkC inhibitor, exhibits high affinity for wild-type recombinant ALK kinase activity with IC50 of 0.7 nM.

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5 mg ￥880 In stock
10 mg ￥1380 In stock
25 mg ￥2280 In stock
50 mg ￥3780 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Belizatinib (TSR-011) is a potent, dual ALK and TrkA, TrkB and TrkC inhibitor, exhibits high affinity for wild-type recombinant ALK kinase activity with IC50 of 0.7 nM.
Belizatinib (TSR-011) exerts sustained potent inhibition of ALK-dependent tumour growth in mouse models.

物理化学性质&存储条件

分子量 577.745
分子式 C33H44FN5O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-fluoro-N-(6-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-1-((1s,4s)-4-(isopropylcarbamoyl)cyclohexyl)-1H-benzo[d]imidazol-2-yl)benzamide

参考文献

1. Sullivan I, et al. Ther Adv Med Oncol. 2016 Jan;8(1):32-47.

2. Iams WT, et al. Cancer J. 2015 Sep-Oct;21(5):378-82.

3. Khotskaya YB, et al. Pharmacol Ther. 2017 May;173:58-66.

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