Balovaptan |CAS:1228088-30-9 Probechem Biochemicals

Chemical Structure : Balovaptan

CAS No.: 1228088-30-9

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Balovaptan (RG7314; RG-7314; RO5285119)

货号: PC-60033Not For Human Use, Lab Use Only.

Balovaptan (RG7314, RO5285119) is a potent, selective vasopressin-1 receptor antagonist with Kb of 0.39 nM at the human V1a receptor.

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10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3680	In stock
100 mg		Get quote

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生物&药学活性

Balovaptan (RG7314, RO5285119) is a potent, selective vasopressin-1 receptor antagonist with Kb of 0.39 nM at the human V1a receptor.

Balovaptan (RG7314, RO5285119)displays outstanding functional selectivity against human V2 (3888-fold) and OT (2735-fold) receptors.

Balovaptan (RG7314, RO5285119) also shows no significant off-target activities except for the human 5HT2B receptor in a diverse 120-target selectivity screen.

物理化学性质&存储条件

分子量	409.918
分子式	C22H24ClN5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-chloro-5-methyl-1-{trans-4-[(pyridin-2-yl)oxy]cyclohexyl}-5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

参考文献

1. Schnider P, et al. J Med Chem. 2020 Feb 27;63(4):1511-1525.

Balovaptan (RG7314; RG-7314; RO5285119)

生物&药学活性

物理化学性质&存储条件

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Balovaptan (RG7314; RG-7314; RO5285119)

生物&药学活性

物理化学性质&存储条件

参考文献

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