欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-抗体药物偶连体和PROTACs-PROTAC-BTX-6654
BTX-6654

Chemical Structure : BTX-6654

CAS No.:

加入收藏

BTX-6654 (BTX6654)

货号: PC-21882Not For Human Use, Lab Use Only.

BTX-6654 is a potent, selective SOS1 cereblon-based bifunctional PROTAC degrader, reduces downstream signaling markers, pERK and pS6, and displayed antiproliferative activity in cells harboring various KRAS mutations.

规格 价格 库存 数量
50 mg Get quote
100 mg Get quote
200 mg Get quote
1 g Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

BTX-6654 is a potent, selective SOS1 cereblon-based bifunctional PROTAC degrader, reduces downstream signaling markers, pERK and pS6, and displayed antiproliferative activity in cells harboring various KRAS mutations.

物理化学性质&存储条件

分子量 940.06
分子式 C50H57F4N9O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(6-fluoro-5-(1-(3-(4-(4-(1-methyl-4-(((R)-1-(2-methyl-3-(trifluoromethyl)phenyl)ethyl)amino)phthalazin-6-yl)piperazine-1-carbonyl)piperidin-1-yl)-3-oxopropyl)piperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

参考文献

1. Kyle Begovich, et al. Mol Cancer Ther. 2024 Jan 15. doi: 10.1158/1535-7163.MCT-23-0513.

2. Johnson JK, et al. ACS medicinal chemistry letters 2016;7(8):785–90

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: