BSJ-05-037 | ITK PROTAC | Probechem Biochemicals

Chemical Structure : BSJ-05-037

加入收藏

BSJ-05-037 (ITK degrader BSJ-05-037)

货号: PC-20466Not For Human Use, Lab Use Only.

BSJ-05-037 is a potent and selective heterobifunctional degrader of ITK with DC50 of 17.6-41.8 nM in TCL lines DERL-2 and Hut78.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

BSJ-05-037 is a potent and selective heterobifunctional degrader of ITK with DC50 of 17.6-41.8 nM in TCL lines DERL-2 and Hut78.
BSJ-05-037 induces potent degradation of ITK dependent on CRBN, neddylation, and the proteasome.
BSJ-05-037 induces GATA-3 loss and decreases chemotherapy resistance in vitro.
BSJ-05-037 disrupts TCR signaling, downregulates the Th2-associated transcription factor GATA-3, and can overcome chemotherapy resistance in TCL models in vivo.

物理化学性质&存储条件

分子量	1022.21
分子式	C51H59N9O10S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-((5-(4-acetylpiperazine-1-carbonyl)-4-methoxy-2-methylphenyl)thio)thiazol-2-yl)-4-(4-(7-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)heptyl)piperazin-1-yl)benzamide

参考文献

1. Jiang B, et al. Cell Chem Biol. 2023 Mar 27:S2451-9456(23)00086-7.

BSJ-05-037 (ITK degrader BSJ-05-037)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

BSJ-05-037 (ITK degrader BSJ-05-037)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.