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首页-抗体药物偶连体和PROTACs-PROTAC-BSJ-03-123
BSJ-03-123

Chemical Structure : BSJ-03-123

CAS No.: 2361493-16-3

BSJ-03-123

货号: PC-35936Not For Human Use, Lab Use Only.

BSJ-03-123 is a potent, CDK6-selective small-molecule degrader (PROTAC) that uniquely enables rapid pharmacological interrogation of CDK6-dependent functions.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BSJ-03-123 is a potent, CDK6-selective small-molecule degrader (PROTAC) that uniquely enables rapid pharmacological interrogation of CDK6-dependent functions.
BSJ-03-123 induces differential E3 ligase recruitment and ensuing degradation of CDK6, but not CDK4.

物理化学性质&存储条件

分子量 936.036
分子式 C48H57N9O11
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(2-(2-(2-(2-(4-(6-((3-acetyl-1-cyclopentyl-4-methyl-2-oxo-1,2-dihydro-1,6-naphthyridin-7-yl)amino)pyridin-3-yl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide

参考文献

1. Brand M, et al. Cell Chem Biol. 2018 Nov 22. pii: S2451-9456(18)30413-6. doi: 10.1016/j.chembiol.2018.11.006.

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