BRD9 degrader ZZ7

Chemical Structure : BRD9 degrader ZZ7

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货号: PC-25575Not For Human Use, Lab Use Only.

BRD9 degrader ZZ7 is a specific, reversible covalent molecular glue degrader that selectively degrades BRD9, covalently engages DCAF16 at Cys178.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

BRD9 degrader ZZ7 is a specific, reversible covalent molecular glue degrader that selectively degrades BRD9, covalently engages DCAF16 at Cys178.
ZZ7 is a proteasomal pathway-dependent BRD9 molecular glue degrader.
ZZ7 recruits DCAF16 to induce the degradation of BRD9. induces selective degradation of BRD9 in synovial sarcoma cells, with minimal effect on human iPSC-derived cardiomyocytes.
ZZ7 shows antiproliferative activity synovial sarcoma cell lines HS-SY-II and 1273/99 with IC50 of 322 nM and 426 nM respectively.
ZZ7 induces tissue-specific BRD9 degradation, resulting in a potent and selective antiproliferative effect against synovial sarcoma cells while potentially avoiding the cardiac side effects associated with clinical-stage BRD9 degraders.

物理化学性质&存储条件

分子量	655.80
分子式	C36H45N7O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-2-(4-(2,6-dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)benzyl)piperazine-1-carbonyl)-4-methyl-4-(4-(oxetan-3-yl)piperazin-1-yl)pent-2-enenitrile

参考文献

1. Byun WS, et al. J Am Chem Soc. 2025 Sep 17. doi: 10.1021/jacs.5c09857.