BRD9 PROTAC C6

Chemical Structure : BRD9 PROTAC C6

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货号: PC-23329Not For Human Use, Lab Use Only.

BRD9 PROTAC C6 is a potent, selective and orally active BRD9 PROTAC degrader with DC50 of 1.02 nM in MV4-11 cells (24 h), without effect on BRD4 or BRD7.

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生物&药学活性

BRD9 PROTAC C6 is a potent, selective and orally active BRD9 PROTAC degrader with DC50 of 1.02 nM in MV4-11 cells (24 h), without effect on BRD4 or BRD7.
C6 has IC50 value of 3.69 ± 3.58 nM in MV4-11 CTRL cells.
C6 exhibited significantly oral activity in ICR mice with the Cmax value of 3436.95 ng/mL.

物理化学性质&存储条件

分子量	649.70
分子式	C36H35N5O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(4-(2,6-dimethoxy-4-(2-methyl-1-oxo-1,2-dihydroisoquinolin-4-yl)benzyl)piperazin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

参考文献

1. Zhang J, et al. Eur J Med Chem. 2023 Oct 17;262:115872.

BRD9 PROTAC C6

生物&药学活性

物理化学性质&存储条件

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BRD9 PROTAC C6

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物理化学性质&存储条件

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