BQU57 | Ral inhibitor | Probechem Biochemicals

Chemical Structure : BQU57

CAS No.: 1637739-82-2

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BQU57 (BQU-57, BQU057)

货号: PC-43278Not For Human Use, Lab Use Only.

BQU57 is a specific small molecule inhibitor of GTPase Ral, inhibits both RalA and RalB activation and colony formation of Ral-dependent lines H2122 and H358 in soft agar with IC50 of 2.0 and 1.3 uM, respectively.

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生物&药学活性

BQU57 is a specific small molecule inhibitor of GTPase Ral, inhibits both RalA and RalB activation and colony formation of Ral-dependent lines H2122 and H358 in soft agar with IC50 of 2.0 and 1.3 uM, respectively.
BQU57 acts specifically through the GDP-bound form of Ral proteins, RalAG23V or RalBG23V, mitigates inhibition of H2122 and H358 cell growth.
BQU57 shows selectivity for Ral relative to Ras or Rho and inhibits xenograft tumor growth similar to depletion of Ral by siRNA.

物理化学性质&存储条件

分子量	334.2958
分子式	C16H13F3N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: ≥ 36 mg/mL
Chemical Name/SMILES	Pyrano[2,3-c]pyrazole-5-carbonitrile, 6-amino-1,4-dihydro-1,3-dimethyl-4-[4-(trifluoromethyl)phenyl]-

参考文献

1. Yan C, et al. Nature. 2014 Nov 20;515(7527):443-7.

BQU57 (BQU-57, BQU057)

生物&药学活性

物理化学性质&存储条件

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BQU57 (BQU-57, BQU057)

生物&药学活性

物理化学性质&存储条件

参考文献

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