BMS-986020 (AM152) | LPA1 antagonist | Probechem Biochemicals

Chemical Structure : BMS-986020

CAS No.: 1257213-50-5

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BMS-986020 (BMS986020, AM-152, AM152)

货号: PC-42213Not For Human Use, Lab Use Only.

BMS-986020 (BMS986020, AM152) is a potent, selective, orally available LPA1 receptor antagonist with Kb value of 6.7 nM.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

BMS-986020 (BMS986020, AM152) is a potent, selective, orally available LPA1 receptor antagonist with Kb value of 6.7 nM.

BMS-986020 has been reported to have an IC50 value < 300 nM for human LPA1, whereas that for LPA3 was about 1-10 μM.

BMS-986020 shows potential for lung fibrosis and psoriasis, against both acute and sub-acute injuries after ischemic stroke by employing a mouse model with transient middle cerebral artery occlusion (tMCAO).

物理化学性质&存储条件

分子量	482.5271
分子式	C29H26N2O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 64 mg/mL
Chemical Name/SMILES	Cyclopropanecarboxylic acid, 1-[4'-[3-methyl-4-[[[(1R)-1-phenylethoxy]carbonyl]amino]-5-isoxazolyl][1,1'-biphenyl]-4-yl]-

参考文献

1. Kihara Y, et al. Exp Cell Res. 2015 May 1;333(2):171-7.
2. Gaire BP, et al. Antioxidants (Basel). 2020 Nov 8;9(11):1097.

BMS-986020 (BMS986020, AM-152, AM152)

生物&药学活性

物理化学性质&存储条件

参考文献

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询单

BMS-986020 (BMS986020, AM-152, AM152)

生物&药学活性

物理化学性质&存储条件

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