BMS-846372 | CGRP antagonist | Probechem Biochemicals

Chemical Structure : BMS-846372

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BMS-846372 (BMS846372)

货号: PC-72952Not For Human Use, Lab Use Only.

BMS-846372 (BMS846372) is a potent, selective, orally active CGRP receptor antagonist with Ki of 0.07 nM (hCGRP).

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生物&药学活性

BMS-846372 (BMS846372) is a potent, selective, orally active CGRP receptor antagonist with Ki of 0.07 nM (hCGRP).
BMS-846372 inhibited CGRP-stimulated cAMP production in SK-N-MC cells with IC50 of 0.22 nM, could completely inhibited CGRP-mediated elevation of cAMP.
BMS-846372 showed exposure-dependent inhibition of CGRP-induced increases in marmoset facial blood flow upon subcutaneous (sc) dosing in hαCGRP-induced increases in facial blood flow model.

物理化学性质&存储条件

分子量	519.553
分子式	C28H27F2N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(6R,9R)-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate

参考文献

1. Guanglin Luo, et al. ACS Med Chem Lett. 2012 Feb 27;3(4):337-41.

BMS-846372 (BMS846372)

生物&药学活性

物理化学性质&存储条件

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询单

BMS-846372 (BMS846372)

生物&药学活性

物理化学性质&存储条件

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