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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Casein Kinase-BMS-595
BMS-595

Chemical Structure : BMS-595

CAS No.:

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BMS-595 (BMS595)

货号: PC-35614Not For Human Use, Lab Use Only.

BMS-595 (BMS595) is a novel potent, selective, ATP-competitive casein kinase 2 (CK2) inhibitor with IC50 of 1.3 nM (CKα).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

BMS-595 (BMS595) is a novel potent, selective, ATP-competitive casein kinase 2 (CK2) inhibitor with IC50 of 1.3 nM (CKα); displays >500-fold selectivity over Auraro B, GSK-3β, PDGFRβ, and no significant activity against CDK2 and Pim1; inhibits the in vitro proliferation of human colorectal and lung cancer cell lines with an IC50 ranging from 10 nM to greater than 1 uM (EL4 cell IC50=0.208 uM); demonstrates potent antitumor effects in combination with anti-CTLA4 antibody.

物理化学性质&存储条件

分子量
分子式
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Hashimoto A, et al. Cancer Res. 2018 Aug 23. pii: canres.1229.2018. doi: 10.1158/0008-5472.CAN-18-1229.

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