BKI-1748

Chemical Structure : BKI-1748

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货号: PC-24759Not For Human Use, Lab Use Only.

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250 mg		Get quote

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生物&药学活性

BKI-1748 a small molecule bumped kinase inhibitor targeting calcium dependent protein kinase 1 (CDPK1), inhibits TgCDPK1 and NcCDPK1 enzyme activities at low nM-concentrations, inhibits proliferation of apicomplexan parasites with EC50 of 165 nM for N. caninum and 43 nM for T. gondii.
BKI-1748 exhibits efficacy against acute and chronic T. gondii infection with RH- and Prugniaud-strains, respectively.
BKI-1748 shows synergistic and additive effects against Neospora caninum infection in vitro and in vivo when combined with ELQ-316.
BKI-1748 exhibits a good efficacy against Toxoplasma gondii infection in vitro and in mouse models.

物理化学性质&存储条件

分子量	369.43
分子式	C19H23N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-amino-3-(2-ethoxyquinolin-6-yl)-1-(1-hydroxy-2-methylpropan-2-yl)-1H-pyrazole-4-carboxamide

参考文献

1. Imhof D, et al. Int J Parasitol Drugs Drug Resist. 2021 Aug;16:90-101.

2. Müller J, et al. Int J Mol Sci. 2022 Feb 21;23(4):2381.

3. Sánchez-Sánchez R, et al. J Infect Dis. 2024 Feb 14;229(2):558-566.

BKI-1748

生物&药学活性

物理化学性质&存储条件

参考文献

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BKI-1748

生物&药学活性

物理化学性质&存储条件

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