BI 167107 |CAS:1202235-68-4 Probechem Biochemicals

Chemical Structure : BI 167107

CAS No.: 1202235-68-4

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BI 167107 (BI-167107, BI167107)

货号: PC-35028Not For Human Use, Lab Use Only.

BI 167107 is a highly potent agonist of the β2 adrenergic receptor (β2AR) and β1AR (IC50=3.2 nM) and shows some activity as α1A antagonist (IC50 = 32 nM).

规格	价格	库存
5 mg	￥2480	In stock
10 mg	￥3980	In stock
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

BI 167107 is a highly potent agonist of the β2 adrenergic receptor (β2AR) and β1AR (IC50=3.2 nM) and shows some activity as α1A antagonist (IC50 = 32 nM).
Due to its high potency and slow dissociation from the target BI-167107 was subsequently used to support crystallization of active state β2AR and β2AR-G-protein complexes.

物理化学性质&存储条件

分子量	370.449
分子式	C21H26N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-hydroxy-8-(1-hydroxy-2-((2-methyl-1-(o-tolyl)propan-2-yl)amino)ethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one

参考文献

1. Weiss DR, et al. ACS Chem Biol. 2013 May 17;8(5):1018-26.

2. Ring AM, et al. Nature. 2013 Oct 24;502(7472):575-579.

3. Manglik A, et al. Cell. 2015 May 21;161(5):1101-1111.

4. Kahsai AW, et al. Nat Chem Biol. 2016 Sep;12(9):709-16.

BI 167107 (BI-167107, BI167107)

生物&药学活性

物理化学性质&存储条件

参考文献

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BI 167107 (BI-167107, BI167107)

生物&药学活性

物理化学性质&存储条件

参考文献

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