BH400 | PPARα agonist/STING inhibitor | Probechem Biochemicals

Chemical Structure : BH400

加入收藏

BH400 (BH 400, BH-400)

货号: PC-22732Not For Human Use, Lab Use Only.

BH400 is a potent, bifunctional PPARα/STING modulator, agonizes PPARα (EC50=1.2 μM) and inhibits STING (IC50=8.1 μM).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

BH400 is a potent, bifunctional PPARα/STING modulator, agonizes PPARα (EC50=1.2 μM) and inhibits STING (IC50=8.1 μM).
BH400 (0-10 uM) shows dose-dependent protection against CoCl2-induced reactive oxygen species (ROS) in HMC3 cells (microglial cell line), rescues the expression of PCG1α following the LPS treatment, reduces LPS-induced secretion of interleukin 6 (IL-6).
BH400 shows superior protection of cell viability over selective STING inhibition. BH400 exhibits superior protection against ROS production in microglial cells (HMC3) compared with selective PPARα agonism and an improvement in photoreceptor (661W) cell viability beyond that observed for selective STING inhibition.
BH400 exhibits PPARα agonistic and STING inhibitory dual modulation activity.

物理化学性质&存储条件

分子量	337.35
分子式	C20H16FNO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(((4'-fluoro-[1,1'-biphenyl]-4-yl)methyl)amino)-2-hydroxybenzoic acid

参考文献

1. Bo Hu, et al. ACS Medicinal Chemistry Letters, July 22, 2024

BH400 (BH 400, BH-400)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

BH400 (BH 400, BH-400)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.